Our focus
is the health and beauty of our patient's skin and the treatment of skin disease.
About Us
Our Dermatologists Specialize
in medical dermatological care as well as comprehensive cosmetic services.
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Our Friendly Dermatologist Staff
Puts forth every effort to make you feel welcome, regardless of background, lifestyle, gender, age or condition
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Welcome to the dermatology office of

David J. MacGregor, MD

We provide state-of-the-art patient care, personalized attention, and up-to-date and innovative treatment methods for dermatological care. In addition, we provide comprehensive cosmetic services. Best dermatologist in San Francisco.
About 450Derm

Our Patient Reviews

John Chinchiolo
Patient Review
Dr MacGregor is amazing! The best at giving Botox in the field! I highly recommend his service!
Kiki Carr (Kiki Q)
Patient Review
Dr. MacGregor was very empathetic, patient and thorough. After fighting this skin condition for months on my own or thru a Teledoc, his treatment is finally clearing it up! So relieved ā€“ since I'm in a wedding in less than a week!
Inna Kagan
Patient Review
Dr. MacGregor is incredibly professional, warm and efficient. Wonderful doctor, really attentive and caring.
Katelyn Caine
Patient Review
I feel so seen + cared for!!!!
Alex Rothwell
Patient Review
Dr MacGregor is Super ! 5 plus stars ! He very much knows how to inject Sculptura. My facial wasting from HIV is not noticeable I am back to what I always remembered my self as. Thank you Dr MacGregor šŸŒž
Kiki Carr (Kiki Q)
Patient Review
Dr. MacGregor was very empathetic, patient and thorough. After fighting this skin condition for months on my own or thru a Teledoc, his treatment is finally clearing it up! So relieved ā€“ since I'm in a wedding in less than a week!
Ana Claudia Pereira
Patient Review
It was my first time meeting him, and my first impression was great. He is kind and patient. He seemed very Confident in the subject, and was very clear explaining the diagnosis.
Tina Spencer
Patient Review
Love Dr. MacGregor! He's a no-nonsense doc who knows his stuff, answers all your questions and entertains all your fears without judgement. The front desk staff is helpful and nice and his office is in the most lovely building in SF. Makes the experience even better.
Darcy Brown
Patient Review
I trust Dr. MacGregor completely. He has transformed my skin!
Ellen Kocins
Patient Review
Dr MacGregor provides outstanding dermatology care. Iā€™m very fortunate I met him when I did as he found a melanoma growth that a previous Dr had overlooked. He referred me immediately to a melanoma specialist and I had surgery within two weeks. Iā€™m very grateful and now will do regular checkups plus graceful-aging visits with Dr MacGregor and his team.
Ted Bartlett
Patient Review
Dr. MacGregor is best in class who listens and communicates perfectly. He is always on time. His staff is very intelligent and professional. I am grateful that he is my dermatologist and only wish I wore sunblock in the 20th Century. As I get older, he keeps me looking young with his excellent cosmetic options. 6 or more stars if that was an option.
Amy Vine
Patient Review
Every time I visit Dr. MacGregor (& staff), I always encounter focused attention on my skin care needs & immediate, honest, professional resolution to some intense infections that I had & which were quickly resolved. I was told 10 years ago by my sorority sister that Dr. Mac Gregor was the best dermatologist in SF. Happy to say that this statement still holds true. Highly recommend!
Russell Pofsky
Patient Review
Simply the best. Stop reading reviews and experience my favorite doctor for yourself. A++
Denise Quinn
Patient Review
Perfect. Easy in and out. The staff and office were excellent and Dr. MacGregor is very professional, skilled and makes the patient feel comfortable.
Rena Ramirez
Patient Review
Dr MacGregor is a skin magician. Always professional; super effective. I trust no one else with my face.
See all 1,799 Google reviews

Patient Portal

If you are a new or existing patient, the easiest way to interact with us or set appointments is by using our easy to use Patient Portal.

Patient Portal

Our Office

Our office is located on the 18th floor of the historic 450 Sutter Medical Office Building, near Union Square in downtown San Francisco.

Our Office
American Academy of Dermatology
American Board of Dermatology
CalDerm
American Society for Dermatology Surgery

Please review our Personal Health Policy

About Us